Immunology Ontologies: Difference between revisions

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== Events ==
== Events ==
   
   
June 11-13, 2012 :'''[http://www.bioontology.org/wiki/index.php/Immunology_Ontologies_and_Their_Applications_in_Processing_Clinical_Data Immunology Ontologies and Their Applications in Processing Clinical Data]'''
June 11-13, 2012 :'''[http://www.bioontology.org/wiki/index.php/Immunology_Ontologies_and_Their_Applications_in_Processing_Clinical_Data Immunology Ontologies and Their Applications in Processing Clinical Data]'''
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September 4-5, 2013
September 4-5, 2013
:'''[http://ncorwiki.buffalo.edu/index.php/ImmPort_Ontology_Conference ImmPort Ontology Conference]''', Stanford University.
:'''[http://ncorwiki.buffalo.edu/index.php/ImmPort_Ontology_Conference ImmPort Ontology Conference]''', Stanford University.
October 3, 2013
[http://ncor.buffalo.edu/2014/Diehl-Ontology-Update-10-3-13.pptx Ontology Update: Antibodies, Proteins Cells], Alexender Diehl
:ImmPort Science Group
10-3-13 Science Meeting


Oct 9-10, 2013  
Oct 9-10, 2013  
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March 18, 2014
March 18, 2014
:'''[[Discussion with Labkey]]'''
:'''[[Discussion with Labkey]]'''
March 20, 2014
:'''[http://ncor.buffalo.edu/2014/Gene-Expression-and-Identity.pptx Gene Expression and Cell Identity], Alexender Diehl
:ImmPort Science Group


==Powerpoint Presentations==
==Powerpoint Presentations==


Barry Smith, [http://ncor.buffalo.edu/2013/Immunology/Slides/Discoverability.pptx Strategies to Enhance Discoverability of Clinical Trial Data]
Barry Smith, [http://ncor.buffalo.edu/2013/Immunology/Slides/Discoverability.pptx Strategies to Enhance Discoverability of Clinical Trial Data]

Revision as of 17:54, 20 March 2014

Background

This page has been created to support the ontology work of the Immunology Database and Analysis Portal (ImmPort) portal within the framework of the Bioinformatics Integration Support Contract (BISC), which is funded by the NIH’s National Institute of Allergy and Infectious Diseases (NIAID). ImmPort is designed to enable scientists to easily access and exchange interoperable complex data sets to accelerate scientific discovery. It provides advanced information technology support in the production, analysis, archiving, and exchange of scientific data for the diverse community of life science researchers supported by NIAID.

The huge plasticity of the immune response, the strong dependence upon the context in which it occurs and on physiological and pathological conditions, and the wide range of responses elicited, make immunology an especially challenging domain for data integration.

The ontologies documented below are designed to enhance the degree to which immunology research results can be expressed in a consistent fashion across communities and disciplines, thus advancing not only the analysis and integration of data but also its discoverability by scientists who were not involved in its creation. In this way, they will contribute to the realization of the goals of ImmPort to accelerate a more collaborative and coordinated research environment and create an integrated database. that broadens the usefulness of scientific data and advances hypothesis-driven and hypothesis-generating research, as well as the development of optimal methods for data collection, storage, exchange and interoperability.

The team of University at Buffalo ontologists with primary responsibility for this work includes:

  • Barry Smith, Professor of Philosophy, Neurology and Computer Science and Director of the National Center for Ontological Research.
  • Alexander Diehl, UB Department of Neurology
  • Alan Ruttenberg, UB Department of Oral Biology and Institute for Healthcare Informatics.

For further background see: http://www.buffalo.edu/news/releases/2009/01/9857.html

Ontologies

Recommended

Chemical Entities of Biological Interest (CHEBI)

The Protein Ontology (PRO)

The Gene Ontology (GO)

GO Annotation for the Immune System

The Cell Ontology (CL)

The Immune Epitope Ontology (ONTIE)

The Infectious Disease Ontology (IDO)

Ontology for Biomedical Investigations (OBI)

Ontology for General Medical Science (OGMS)


Desiderata

Allergy Ontology

Immunology Ontology


Awaiting review

Immune Disorder Ontology (IMMDIS)


Passed over

Ontology for Immunogenetics IMGT (unfortunately developed with no concern for interoperability with other ontologies)

Ontology Consortia

OBO (Open Biological and Biomedical Ontologies) Foundry

Collaboration between Immport, CyTOF and the Cell Ontology

Clinical Trial Ontology / CDISC

Portals

Immunology Database and Analysis (ImmPort) Portal

NCBO Bioportal (ontology repository)

Ontobee (ontology visualization portal)

HIPC: Human Immunology Project Consortium

Program for Research on Immune Modeling and Experimentation PRIME

Immune Epitope Database and Analysis Resource

Publications

Maecker, H., McCoy, J.P. & Nussenblatt, R. Standardizing immunophenotyping for the human immunology project. Nature reviews Immunology 12, 191-200 (2012).

Smith B, Ashburner M, Rosse C, Bard J, Bug W, Ceusters W, Goldberg LJ, Eilbeck K, Ireland A, Mungall CJ; OBI Consortium, Leontis N, Rocca-Serra P, Ruttenberg A, Sansone SA, Scheuermann RH, Shah N, Whetzel PL, Lewis S. , The OBO Foundry: Coordinated Evolution of Ontologies to Support Biomedical Data Integration, Nature Biotechnology, 25 (11), November 2007, 1251-1255.

Cowell LG, Smith B, Infectious Disease Ontology, in Vitali Sintchenko, Infectious Disease Informatics, New York: Springer, December 2009, 373-395.

Masci AM, Arighi CN, Diehl AD, Lieberman AE, Mungall C, Scheuermann RH, Smith B, Cowell LG, An improved ontological representation of dendritic cells as a paradigm for all cell types, BMC Bioinformatics, February 2009, 10:70.

Diehl AD, Augustine AD, Blake JA, Cowell LG, et al. Hematopoietic cell types: prototype for a revised cell ontology. J Biomed Inform. 2011; 44(1).

Meehan TF, Masci AM, Abdulla A, Cowell LG, et al. Logical development of the cell ontology. BMC Bioinformatics. 2011; 12.

Goldfain A, Smith B, Cowell LG, Towards an Ontological Representation of Resistance: The Case of MRSA, Journal of Biomedical Informatics, 2011 (Feb.), 44:1, 35-41.

Scheuermann RH, Ceusters W, Smith B, Toward an Ontological Treatment of Disease and Diagnosis, Proceedings of the 2009 AMIA Summit on Translational Bioinformatics, 2009, 116-120.

Goldfain A, Smith B, Cowell LG, Dispositions and the Infectious Disease Ontology, in Antony Galton and Riichiro Mizoguchi (eds.), Formal Ontology in Information Systems. Proceedings of the Sixth International Conference (FOIS 2010), Amsterdam: IOS Press, 2010, 400-413.

Goldfain A, Smith B, Cowell LG, [http://ontology.buffalo.edu/smith/articles/ICBO2012/IDO_Lattice.pdf Constructing a Lattice of Infectious Disease Ontologies from a Staphylococcus aureus Isolate Repository”, Proceeedings of the Third International Conference on Biomedical Ontology, Graz, July 23-25, 2012 (CEUR, vol. 897).

Cox AP, Jensen M, Duncan W, Weinstock-Guttman B, Szigeti K, Ruttenberg A, Smith B, Diehl AD, Ontologies for the Study of Neurological Disease, Towards an Ontology of Mental Functioning (ICBO Workshop), Third International Conference on Biomedical Ontology, Graz, July 22, 2012.

Yu AC, Smith B, Schwartz S, [http://ontology.buffalo.edu/medo/ACAAI-2012.pdf Formal and Computable Representations of Allergic Diseases in the Electronic Health Record: An Approach Based on the Ontology of General Medical Science, 2012 Annual Meeting of the American College of Allergy, Asthma & Immunology (ACAAI), November 8-13, 2012, Anaheim, California (Poster).

Events

June 11-13, 2012 :Immunology Ontologies and Their Applications in Processing Clinical Data

April 8, 2013

1st ImmPort Ontology Group Web Conference:
4:00pm Lindsay Cowell (UT Southwestern): The VDJ Server
5:00pm General discussion of CL and CyTOF

April 22, 2013

2nd ImmPort Ontology Group Web Conference
4:00pm Nikolay Samusik (Stanford): Charting the reference map of the immune system using CyTOF data

April 29, 2013

3rd Immport Ontology Group Web Conference
4:00pm Yannick Pouliot (Stanford): Peak Probability Contrasts (PPC)

June 11, 2013

Lecture and practical session on Immunology Ontology
Summer School for Quantitative Systems Immunology, Boston, MA.

June 24, 2013

4th Immport Ontology Group Web Conference

August 1, 2013

Barry Smith (Buffalo): How to make ImmPort data fit for secondary use
Presentation to Immport Science Group Weekly Meeting

September 4-5, 2013

ImmPort Ontology Conference, Stanford University.

October 3, 2013 Ontology Update: Antibodies, Proteins Cells, Alexender Diehl

ImmPort Science Group

10-3-13 Science Meeting

Oct 9-10, 2013

Training and Strategy Workshop for ImmPort Data Submitters, Rho Federal Systems Division, Chapel Hill, NC, October 9-10

January 21, 2014

Clinical Trial Data Wants to be Free
Presentation by Barry Smith, University at Buffalo Clinical and Research Ethics Seminar

February 27, 2014

Enhancing the Quality of ImmPort Data, Immport Science Group

March 13, 2014

5th ImmPort Ontology Group Web Conference
Presentation by Ravi Shankar on the Clinical Trial Ontology

March 18, 2014

Discussion with Labkey

March 20, 2014

Gene Expression and Cell Identity, Alexender Diehl
ImmPort Science Group

Powerpoint Presentations

Barry Smith, Strategies to Enhance Discoverability of Clinical Trial Data