Difference between revisions of "PRO Consortium Workshop 2019"

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::Connecting proteins to disease using Disease pathways (Peter)
:Drug targets (Stephan Schürer)
::Drug targets (Stephan Schürer)
:Connecting antibodies to epitopes and proteins (Randi Vita)
::Connecting antibodies to epitopes and proteins (Randi Vita)
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:17:30 Close of Day 1

Revision as of 15:40, 19 August 2019

Date: October 23-24, 2019


Protein Informatics Resource
Georgetown University Medical Center
3300 Whitehaven Street, NW, Suite 1200
Washington, DC 20007, USA


The goals of this meeting are:

  • 1. To plan the future of the PRO
  • 2. To foster PRO's collaborations with other initiatives

Schedule: Wednesday, October 23, 2019

8:30 Breakfast

PRO as a framework for advancing disease understanding

Chair: Darren Natale

9:00 Introduction
General introduction to PRO (Darren Natale)
Protein aggregates here? (Alexander Diehl)
PRO sites (Alan Ruttenberg)
10:30-10:45 Break

Disease mechanisms: connecting clinically-relevant protein sequence variations with their impact on underlying molecular mechanisms

Chair: Judith Blake

10:30 Mouse models of human disease (TBD)
UniProtKB's molecular impact information (Harold Drabkin?)
Disease Ontology (Melody Swan)
Ontology for General Medical Science (Barry Smith)
Discovering molecular mechanisms underlying disease (Karen Ross, Natarajan Kannan)
12:30-13:30 Lunch
12:30-13:30 Lunch

Clinical discovery: connecting clinically-relevant information to proteoforms and complexes

Chair: Peter d'Eustachio

13:30 Connecting proteins to disease using Disease pathways (Peter d'Eustachio)
Drug targets (Stephan Schürer)
Connecting antibodies to epitopes and proteins (Randi Vita)
17:30 Close of Day 1
18:00 Working dinner

Schedule: Thursday, October 24, 2019

4) Cell type discovery: connect proteoform expression profiles with clinically-relevant cell types

Chair: Alexander Diehl

8:45 Introduction (Alexander Diehl)
scRNA from KPMP (Oliver He)
Proteoform-based cell type dictionary (Alex Diehl)
10:30-11:00 Break



11:00 Introduction
12:30-1:30 Lunch
13:30 Working Session on Grant Proposal
15:00 Close


Alexander Bateman (EBI)*
Alexander Diehl (Buffalo)
Cecilia Arighi (Delaware / PRO)
Judith Blake (JAX)
Peter d'Eustachio (NYU)
Alexander Diehl (Buffalo)
Harold Drabkin (JAX)
Yongqun (Oliver) He (Michigan)
Natarajan Kannan (Georgia)
Richard LeDuc (Northwestern)
Birgit Meldal (EBI)*
Darren Natale (Georgetown)
? Li Ni (JAX)
Karen Ross (Georgetown)
Alan Ruttenberg (Buffalo)
Stephan Schürer (Miami)
Barry Smith (Buffalo)
Christian Stoeckert (Penn)
Melogy Swan (Baltimore)
Paul Martin Thomas (Northwestern)
Randi Vita (San Diego)
Cathy Wu (Delaware / PRO)
  • =online

Please contact Barry Smith for further information.


The Protein Ontology Consortium
National Center for Ontological Research