PRO Consortium Workshop 2019
Date: October 23-24, 2019
Venue:
- Protein Informatics Resource
- Georgetown University Medical Center
- 3300 Whitehaven Street, NW, Suite 1200
- Washington, DC 20007, USA
Goals
The goals of this meeting are:
- 1. To plan the future of the PRO
- 2. To foster PRO's collaborations with other initiatives
Schedule: Wednesday, October 23, 2019
- 8:30 Breakfast
PRO as a framework for advancing disease understanding
Chair: Darren Natale
- 9:00 Introduction
- General introduction to PRO (Darren Natale)
- Protein aggregates here? (Alexander Diehl)
- PRO sites (Alan Ruttenberg)
- 10:30-10:45 Break
Disease mechanisms: connecting clinically-relevant protein sequence variations with their impact on underlying molecular mechanisms. Part 1
Chair: Judith Blake
- 10:45 Mouse models of human disease (TBD)
- 11:15 Standardizations
- UniProt (Alexander Bateman)
- UniProtKB's molecular impact information (Harold Drabkin?)
- 12:30-13:30 Lunch
Disease mechanisms: connecting clinically-relevant protein sequence variations with their impact on underlying molecular mechanisms. Part 1
- 13:30
- Disease Ontology (Melody Swan)
- Ontology for General Medical Science (Barry Smith)
- Discovering molecular mechanisms underlying disease (Karen Ross, Natarajan Kannan)
- 15:30-16:00 Break
- 17:30 Close of Day 1
- 18:00 Working dinner
Schedule: Thursday, October 24, 2019
8:15 Breakfast
Clinical discovery: connecting clinically-relevant information to proteoforms and complexes
Chair: Peter d'Eustachio
- 8:45Connecting proteins to disease using disease pathways (Peter d'Eustachio)
- Drug targets (Stephan Schürer)
- Connecting antibodies to epitopes and proteins (Randi Vita)
- 10:30-11:00 Break
Cell type discovery: connecting proteoform expression profiles with clinically-relevant cell types
Chair: Alexander Diehl
- 11:00 Introduction (Alexander Diehl)
- scRNA from KPMP (Oliver He)
- Proteoform-based cell type dictionary (Alex Diehl)
- 12:30-1:30 Lunch
- 13:30 Working Session (on Grant Proposal)
- 15:00 Close
Participants
- Alexander Bateman (EBI)*
- Alexander Diehl (Buffalo)
- Cecilia Arighi (Delaware / PRO)
- Judith Blake (JAX)
- Peter d'Eustachio (NYU)
- Alexander Diehl (Buffalo)
- Harold Drabkin (JAX)
- Yongqun (Oliver) He (Michigan)
- Natarajan Kannan (Georgia)
- Richard LeDuc (Northwestern)
- Birgit Meldal (EBI)*
- Darren Natale (Georgetown)
- ? Li Ni (JAX)
- Karen Ross (Georgetown)
- Alan Ruttenberg (Buffalo)
- Stephan Schürer (Miami)
- Barry Smith (Buffalo)
- Christian Stoeckert (Penn)
- Melogy Swan (Baltimore)
- Paul Martin Thomas (Northwestern)
- Randi Vita (San Diego)
- Cathy Wu (Delaware / PRO)
- =online
Please contact Barry Smith for further information.
