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	<title>Mungall paper - Revision history</title>
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		<id>https://ncorwiki.buffalo.edu/index.php?title=Mungall_paper&amp;diff=65837&amp;oldid=prev</id>
		<title>Phismith: Created page with &#039;See link to Mungall draft paper on temporalized relations [https://github.com/cmungall/trel-crit/raw/master/trc.pdf here].  &#039;&#039;&#039;Executive Summary&#039;&#039;&#039;   Since their inception, biolo...&#039;</title>
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		<updated>2013-05-13T14:25:49Z</updated>

		<summary type="html">&lt;p&gt;Created page with &amp;#039;See link to Mungall draft paper on temporalized relations [https://github.com/cmungall/trel-crit/raw/master/trc.pdf here].  &amp;#039;&amp;#039;&amp;#039;Executive Summary&amp;#039;&amp;#039;&amp;#039;   Since their inception, biolo...&amp;#039;&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;See link to Mungall draft paper on temporalized relations [https://github.com/cmungall/trel-crit/raw/master/trc.pdf here].&lt;br /&gt;
&lt;br /&gt;
&amp;#039;&amp;#039;&amp;#039;Executive Summary&amp;#039;&amp;#039;&amp;#039; &lt;br /&gt;
&lt;br /&gt;
Since their inception, biological ontologies have made use of a core&lt;br /&gt;
set of relations such as &amp;quot;part of&amp;quot; and &amp;quot;participates in&amp;quot;. These&lt;br /&gt;
relations were standardized and given a formal interpretation with the&lt;br /&gt;
publication of the &amp;quot;Relations in Biomedical Ontologies paper&amp;quot; by Smith&lt;br /&gt;
et al in 2005. Recently there has been a proposal to end support for&lt;br /&gt;
these simple relations and replace them with more complex&lt;br /&gt;
&amp;quot;temporalized relations&amp;quot;, as part of the BFO2 OWL release. Ontology&lt;br /&gt;
developers would need to replace existing relations with temporalized&lt;br /&gt;
ones if they are to be conformant to BFO. The temporalized forms of&lt;br /&gt;
&amp;quot;part of&amp;quot; in the current release are &amp;quot;part of at some times&amp;quot;, &amp;quot;part of&lt;br /&gt;
at all times&amp;quot;, &amp;quot;part of at all times that whole exists&amp;quot;. This set may&lt;br /&gt;
even be extended to more forms in future releases.&lt;br /&gt;
&lt;br /&gt;
This would be a radical change impacting all ontology developers and&lt;br /&gt;
users, requiring complex re-engineering. Normally, such an&lt;br /&gt;
unprecedented major change would have to be justified by a major flaw&lt;br /&gt;
in the current system of simple non-temporalized relations. We might&lt;br /&gt;
expect the flaw to be a major hindrance to ontology development or&lt;br /&gt;
usage, and the new solution to work better. We might also expect the&lt;br /&gt;
flaw to be described in a peer-reviewed publication.&lt;br /&gt;
&lt;br /&gt;
However, this is not the case. There has been no demand from ontology&lt;br /&gt;
developers or their users to make this transition. In fact most&lt;br /&gt;
ontology developers have not been consulted. The sole justification&lt;br /&gt;
for this radical change lies in a formal technicality, concerning the&lt;br /&gt;
difference between the intepretation of relations in the Web Ontology&lt;br /&gt;
Language (OWL) and the temporal interpretation provided in the&lt;br /&gt;
Relations Ontology paper. Most experienced OWL modelers have been&lt;br /&gt;
aware of this misalignment for a number of years, and accept this as a&lt;br /&gt;
trade-off that comes with the benefits of using OWL. This trade-off&lt;br /&gt;
has yet to cause difficulties for practical ontology development and&lt;br /&gt;
use. Ongoing work suggests it may even be possible to find some&lt;br /&gt;
satisfactory solution to the technicality whilst preserving existing&lt;br /&gt;
relations.&lt;br /&gt;
&lt;br /&gt;
Yet despite this lack of mandate, BFO2 does not include simple&lt;br /&gt;
relations and provides temporalized relations in their place.&lt;br /&gt;
&lt;br /&gt;
A number of experienced ontology modelers (including myself) have&lt;br /&gt;
voiced serious concerns about the temporalized relations proposal. In&lt;br /&gt;
addition I observed that less experienced ontology developers and&lt;br /&gt;
users are highly confused by the BFO2 OWL proposal - they did not know&lt;br /&gt;
how to migrate to or how to use the new relations, and they did not&lt;br /&gt;
understand the underlying motivatation for introducing them in the&lt;br /&gt;
first place. It was suggested to me that I collect some my objections&lt;br /&gt;
in a document, which is what I have done in &amp;quot;A critique of BFO2 OWL&lt;br /&gt;
temporalized relations&amp;quot;.&lt;br /&gt;
&lt;br /&gt;
The document provides an overview of the temporalization proposal,&lt;br /&gt;
focusing on the part-of relation (although it should be understood&lt;br /&gt;
that this is for the sake of brevity, and the proposal affects many&lt;br /&gt;
more relations). I describe some of the features of BFO2 OWL that are&lt;br /&gt;
widely accepted: the meaning of the BFO2 OWL relations are different&lt;br /&gt;
from the interpretations in the 2005 Relations paper; important OWL&lt;br /&gt;
characteristics such as transitivity and inverses differ from the&lt;br /&gt;
reference form; temporalization leads to an increased number of&lt;br /&gt;
relations, and these do not always connect together in intuitive&lt;br /&gt;
ways. These are not new findings, but bear highlighting, as many&lt;br /&gt;
potential BFO2 adopters were not previously aware of them.&lt;br /&gt;
&lt;br /&gt;
I then provide an evaluation of BFO2 OWL, using examples from&lt;br /&gt;
ontologies I work on, including the GO. Again, for reasons of space, I&lt;br /&gt;
focus on &amp;quot;part of&amp;quot;. I show that the current version of BFO2 OWL cannot&lt;br /&gt;
accurately represent the parthood relationship between a nucleus and a&lt;br /&gt;
cell without giving up on transitivity, a characteristic that is&lt;br /&gt;
obviously essential. I also show that temporalized relations hinder&lt;br /&gt;
our abilities to use OWL reasoning to check for certain kinds of&lt;br /&gt;
mistakes in ontologies. Finally I demonstrate how the rigidity&lt;br /&gt;
constraint imposed by BFO2 OWL means we cannot include certain&lt;br /&gt;
classes, such as a pre-migratory neural crest cell, in our ontologies.&lt;br /&gt;
&lt;br /&gt;
I consider this to be sufficient to demonstrate that not only does the&lt;br /&gt;
current version of BFO2 OWL force overwhelming complexity onto&lt;br /&gt;
ontologies, it simply will not work.&lt;br /&gt;
&lt;br /&gt;
Recent discussions suggest workarounds for some of the problems I have&lt;br /&gt;
highlighted. These workarounds involve the introduction of even more&lt;br /&gt;
temporalized forms of relations, and the introduction of the concept&lt;br /&gt;
of a history. Because these are neither formalized nor in the BFO2 OWL&lt;br /&gt;
document, I am unable to give a thorough analysis demonstrating my&lt;br /&gt;
concerns with these new proposed extension. However, I include a brief&lt;br /&gt;
section describing these new relations.&lt;br /&gt;
&lt;br /&gt;
My conclusions are that the temporalized relations in BFO2 OWL should&lt;br /&gt;
not be used. They are far, far too complex, and even if this&lt;br /&gt;
complexity could be overcome with significant tool support, they do&lt;br /&gt;
not work in the currently published form. My recommendations are that&lt;br /&gt;
ontology developers continue to use the simple non-temporalized&lt;br /&gt;
relations they are accustomed to using, and that these relations&lt;br /&gt;
should be supported so long as they are required by the&lt;br /&gt;
community. This approach may not be perfect from a formal theoretical&lt;br /&gt;
point of view, but it is essentially the approach that has been used&lt;br /&gt;
for the last decade, and has not been documented to cause problems.&lt;/div&gt;</summary>
		<author><name>Phismith</name></author>
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