PRO Consortium Workshop 2019: Difference between revisions
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'''Disease mechanisms: connecting clinically-relevant protein sequence variations with their impact on underlying molecular mechanisms. Part | '''Disease mechanisms: connecting clinically-relevant protein sequence variations with their impact on underlying molecular mechanisms. Part 2''' | ||
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Revision as of 11:17, 20 August 2019
Date: October 23-24, 2019
Venue:
- Protein Informatics Resource
- Georgetown University Medical Center
- 3300 Whitehaven Street, NW, Suite 1200
- Washington, DC 20007, USA
Goals
The goals of this meeting are:
- 1. To plan the future of the PRO
- 2. To foster PRO's collaborations with other initiatives
Schedule: Wednesday, October 23, 2019
- 8:30 Breakfast
PRO as a framework for advancing disease understanding
Chair: Darren Natale
- 9:00 General introduction to PRO (Darren Natale)
- Protein aggregates (Alexander Diehl)
- PRO sites (Alan Ruttenberg)
- 10:30-10:45 Break
Disease mechanisms: connecting clinically-relevant protein sequence variations with their impact on underlying molecular mechanisms. Part 1
Chair: Judith Blake
- 10:45 Mouse models of human disease (TBD)
- 11:15 UniProt
- UniProt (Alexander Bateman)
- UniProtKB's molecular impact information (Harold Drabkin?)
- There is a need for standardization of information found on UniProtKB's mutation feature lines. Currently this information is provided as free text. It needs to be connected to various ontologies, including the GO. For example, some mutation might abolish some function that could be described using GO.
- 12:30-13:30 Lunch
Disease mechanisms: connecting clinically-relevant protein sequence variations with their impact on underlying molecular mechanisms. Part 2
- 13:30
- Disease Ontology (Melody Swan)
- Ontology for General Medical Science (Barry Smith)
- Discovering molecular mechanisms underlying disease (Karen Ross, Natarajan Kannan)
- 15:30-16:00 Break
- 17:30 Close of Day 1
- 18:00 Working dinner
Schedule: Thursday, October 24, 2019
- 8:15 Breakfast
Clinical discovery: connecting clinically-relevant information to proteoforms and complexes
Chair: Peter d'Eustachio
- 8:45 Connecting proteins to disease using disease pathways (Peter d'Eustachio)
- Drug targets (Stephan Schürer)
- Connecting antibodies to epitopes and proteins (Randi Vita)
- 10:30-11:00 Break
Cell type discovery: connecting proteoform expression profiles with clinically-relevant cell types
Chair: Alexander Diehl
- 11:00 Introduction (Alexander Diehl)
- scRNA from KPMP (Oliver He)
- Proteoform-based cell type dictionary (Alex Diehl)
- 12:30-1:30 Lunch
- 13:30 Working Session (on Grant Proposal)
- 15:00 Close
Participants
- Alexander Bateman (EBI)*
- Alexander Diehl (Buffalo)
- Cecilia Arighi (Delaware / PRO)
- Judith Blake (JAX)
- Peter d'Eustachio (NYU)
- Alexander Diehl (Buffalo)
- Harold Drabkin (JAX)
- Yongqun (Oliver) He (Michigan)
- Natarajan Kannan (Georgia)
- Richard LeDuc (Northwestern)
- Birgit Meldal (EBI)*
- Darren Natale (Georgetown)
- ? Li Ni (JAX)
- Karen Ross (Georgetown)
- Alan Ruttenberg (Buffalo)
- Stephan Schürer (Miami)
- Barry Smith (Buffalo)
- Christian Stoeckert (Penn)
- Melogy Swan (Baltimore)
- Paul Martin Thomas (Northwestern)
- Randi Vita (San Diego)
- Cathy Wu (Delaware / PRO)
- =online
Please contact Barry Smith for further information.