Ontology and Imaging Informatics

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Third Clinical and Translational Science Ontology Workshop

  • Tutorial: June 23, 2014
  • Workshop: June 24-25, 2014

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THIS MEETING IS NOW CLOSED TO FURTHER PARTICIPANTS


Goals

The goal of this meeting is to advance discoverability, interoperability and combinability of biomedical imaging data. It consists of a tutorial providing an introduction to imaging ontology, followed by two days of presentation and discussion of major contributions to biomedical imaging in radiology and digital pathology.

- Day 0 of the workshop will consist in a tutorial providing an introduction to biomedical imaging ontology.

- Day 1 of the workshop will consist in an overview of major contributions to biomedical imaging in radiology and digital pathology with a view towards coordination and exchange of ideas.

- Day 2 will focus on the creation and review of a draft Biomedical Image Ontology and explore how ontology can contribute to the coordination of research across the CTSA consortium with a special reference to digital histopathology imaging.

Tutorial: Monday, June 23

10:00 Registration
10:30 Ulysses Balis: Introduction to Imaging Informatics: The Problem of Image Data Interoperability
12:30 Lunch Buffet
13:30 Barry Smith: Introduction to Ontology for Imaging Informatics
15:00 Refreshment Break
15:30 William Hogan: Ontology in the CTSA Consortium

Workshop - Day 1: Tuesday, June 24

Morning

8:30 Registration and Continental Breakfast
9:00 Participant Introductions
9:15 Keynote Address: Daniel Rubin: Imaging Big Data
Abstract
10:15 Refreshment Break
10:30 Michael J. Becich: An Overview of Standards and Initiatives in Digital Pathology
11:15 Charles Kahn: Radiology Gamuts Ontology: Differential Diagnosis in Radiology (On Gamuts see here.)
12:00 Buffet Lunch

Afternoon

13:00 Michael Calhoun and Ilya Goldberg: Image Language Processing and Encoding
Abstract on the Open Microscopy Environment
13:40 Bernard Gibaud: Ontology of Imaging Datasets as a Prerequisite for Ontologies of Imaging Biomarkers
14:20 James Overton and Heiner Overkampf: Expressing Medical Image Measurements using the Ontology for Biomedical Investigations
15:00 Refreshment Break
15:20 Andrew H. Beck: Imaging Informatics and Ontologies for the Development and Dissemination of Integrative Cancer Diagnostics
16:00 Paolo Ciccarese: Interoperable Biomedical Image Annotations. Describing and Linking Biomedical Images through Open Annotation and Domain Ontologies
16:40 Anna Maria Masci: Immunological Images and the ImmPort Database and Analysis Portal
17:20 Alexander Diehl: The NIF / ImmPort Antibody Registries: Benefits of Consistent Naming
18:00 Reception and Dinner sponsored by the University at Buffalo Department of Biomedical Informatics (No-Host Bar)

Workshop - Day 2: Wednesday, June 25

Morning

8:30 Continental Breakfast
9:00 Practical sessions devoted to creating a strategy to promote comparability and queryability of biomedical image data in general and digital pathology imaging data in particular

Sessions will include:

Alan Ruttenberg: Queryathon
The goal of this session is to sketch a framework which will allow us to assess progress in building an imaging ontology by providing a list of the types of questions which the ontology will allow us to answer. These should be questions for which you think your data suffice to provide answers, but which cannot be effectively asked with current approaches. Questions sent in advance are welcome; please send to [1].
Barry Smith: An Ontology Framework for Biomedical Imaging
Metin N. Gurcan, Anant Madabhushi and John Tomaszewski: Histopathological Image Analysis (HIMA) and Ontology
10:30-10:45 Refreshment Break
William Hogan and Mathias Brochhausen: Biobanking and Digital Pathology: How to Make Ontologies that Work Together
Werner Ceusters: Referent Tracking: How to Use Ontologies to Deal with Instance Data
12:00 Lunch Buffet

Afternoon

13:00 Hackathon: Building an Ontology for Digital Pathology
Facilitators: James Overton and Barry Smith
First draft image ontology based on the Ontology for Biomedical Investigations (OBI):
OWL File
XSL File
The scope of the ontology will be the entire domain of biomedical imaging, including Radiology, Neuro-imaging, and Histopathology; it should also include a branch relating to image-processing algorithms. However, we will focus primarily on populating the branch devoted to (quantitative) histopathology.
16:00 Close of Workshop

Possible starting points for ontology development

1. Quantitative Imaging Biomarker Ontology (QIBO)
Unfortunately QIBO contains no definitions. Suggested top-level mappings from QIBO to OBI/OBO are:
- Acquisition Device -> OBI:device
- Biological Intervention -> OBI:material processing
- Biological Target -> use relations instead of classes
- Biomarker Use -> ~IAO:objective specifications
- Imaging Agent -> ChEBI
- Imaging Agent Source of Emitted Energy -> energy terms need to be added to OBO
- Imaging Subject -> use relations instead of classes
- Imaging Technique -> OBI:assay
- Indicated Biology
- Biological Process -> GO
- Disease -> https://code.google.com/p/ogms/ OGMS], DOID
- Post-processing Algorithm -> OBI:data transformation
- Quantitative Imaging Biomarker -> ~OBI:measurement datum
2. OME Data Model
3. TBD

Sponsors

This meeting forms part of a series of ontology workshops sponsored by the NCBO. A precursor event in this series, devoted to the ontology of images, was held in 2006.

Background

Organizing Committee

Barry Smith (University at Buffalo)

William Hogan (University of Florida)

John Tomaszewski (University at Buffalo)

Participants

Sivaram Arabandi (Ontopro)

Ulysses J. Balis (University of Michigan, Ann Arbor)

Carol Bean (NCBO / Stanford University)

Michael Becich (University of Pittsburgh)

Andrew H. Beck (Harvard Medical School)

Tanja Bekhuis (University of Pittsburgh)

Jonathan Bona (University at Buffalo)

Erich Bremer (Stony Brook Medicine)

Mathias Brochhausen (University of Arkansas for Medical Sciences)

Wiam Bshara (Roswell Park Cancer Institute)

Michael Calhoun (Sinq Systems)

Werner Ceusters (University at Buffalo)

Paolo Ciccarese (Harvard Medical School)

Alexander Cox (University at Buffalo)

Chris Crowner (University at Buffalo)

Alexander Diehl (University at Buffalo)

William Duncan (University at Buffalo)

Michael Dwyer (University at Buffalo)

Peter Elkin (University Buffalo)

Gilberto Fragoso (NCI / NIH)

Carmelo Gaudioso (Roswell Park Cancer Institute)

Bernard Gibaud (LTSI, Rennes)

Allan S. Goldberg (Touro University, California)

Ilya Goldberg (Open Microscopy Initiative / NIH National Institute on Aging)

Metin Gurcan (State University of Ohio)

William Hogan (University of Florida)

Mark Jensen (University at Buffalo)

Charles E. Kahn (Medical College of Wisconsin, Milwaukee)

Venkat N. Krovi (University at Buffalo)

Anant Madabhushi (Case Western Reserve University)

Tatiana Malyuta (CUNY)

Anna Maria Masci (Duke University)

Kevin Mitchell (University of Pittsburgh)

Heiner Oberkampf (Siemens, Munich)

James A. Overton (Knocean, Toronto)

Patrick Ray (University at Buffalo)

Michael Riben, MD (MD Anderson Cancer Center, Houston)

Daniel Rubin (Stanford University)

Alan Ruttenberg (University at Buffalo)

András Sablauer (St Jude Children's Research Hospital, Memphis)

Yonatan Schreiber (University at Buffalo / CUBRC)

Ferdinand Schweser (University at Buffalo)

Selja Seppala (University at Buffalo)

Barry Smith (University at Buffalo)

Dagobert Soergel (University at Buffalo)

Jose Luis Tapia (University at Buffalo)

John Tomaszewski (University at Buffalo)

Eugene Tseytlin (University of Pittsburgh)

Marc van Driel (Philips Research, The Netherlands)

Amber Worral (Roswell Park Cancer Institute)

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