PRO Consortium Workshop 2017

Date: October 11-12, 2017

Venue: Jackson Lab, Bar Habor, Maine

Goals

The goals of this meeting are:

• 1. To review the current state of the Protein Ontology and its relation to other protein-related information resources, especially UniProt and GO
• 2. To assess progress in the use of advanced computational techniques, including Natural Language Processing, in the development of the PRO
• 3. To examine the actual and potential contribution of PRO to the understanding of disease across organisms
• 4. To review PRO's role in the field of immunology informatics
• 5. To advance the treatment of protein-related clinical and translational data from the perspective of consistency, discoverability and support for diagnosis
• 6. To evaluate competing approaches to PRO annotation

Schedule: Tuesday, October, 10, 2017

19:00 Informal reception for early arrivals in conference hotel

Schedule: Wednesday, October, 11, 2017

8:45 Introductory Session: The Landscape of the Protein Ontology

Cathy Wu: Protein Ontology: Its current state and future development

Sites, PTMs

Karen Ross: PRO Collaborations (ProKinO, NeXtProt ...)

Kimberley VanAuken: Noctua

Erich Becker and Elissa Chesler: GeneWeaver

Cindy Smith: The Alliance of Genome Resources

10:30 Break

10:45 PRO and Informatics

Chair: TBD

Chuming Chen: Writing SPARQL queries for PRO

Alan Ruttenberg: Enhanced SPARQL queries for PRO

Cecilia Arighi: The role of NLP in PRO curation

12:30 Lunch

13:30 PRO and Disease

Chair: Darren Natale

Judith Blake: Disease Ontology -- overview of available resources

Chris Mungall: MONARCH

Elissa Chesler: MGI effort to combine variant data with disease forms; Genereader resource, PRO IDs for variants

Barry Smith: Protein-Disease Relations

14:30 Break

14:45 PRO and Disease (Continued)

Peter McGarvey (TBD)

Other large-scale frameworks working with protein variants

Alex Diehl: PRO and the Antibody Ontology

Alex Diehl: PRO and the Cell Ontology

• HIPC, cell populations, the Antibody Panel Ontology, Cell types vs. cell states -- when do combinations of protein markers

16:00 Break

16:15 The Value of PRO Annotations in Enabling Biomedical Ontology-Database Linkage

• This session will include a debate on the proper representation of PRO annotations

between Alan Ruttenberg, Chris Mungall, David Hill and Darren Natale

18:00 Working dinner

Schedule: Thursday, October 12, 2017

Venue: JAX

8:00 Continental breakfast

9:00 GO, PRO and UniProt: How they should work together

Chair: Cathy Wu

Alex Bateman (EBI)

10:30 Break

10:45 TBD

12:00 Lunch

12:45 Debate: How genes are referenced in OBO Foundry and in PRO: why do they differ?

Chair: TBD

Participants: Chris Mungall, Darren Natale, Alan Ruttenberg (could be moved to working dinner if space needed)

14:00 Close of Plenary Sessions

14:00 Working group meetings

17:00 Close

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Participants

Cecilia Arighi (Delaware / PRO)

Erich Baker (Baylor)

Alex Bateman (EBI)

Judith Blake (JAX)

Elissa Chesler (JAX)

Alex Diehl (Buffalo)

Harold Drabkin (JAX)

? Gang Fu (NCBI / NIH)

Peter McGarvey (Georgetown)

? Donna Maglott (NIH / NLM / NCBI)

Chris Mungall (LBNL)

Darren Natale (Georgetown)

Li Ni (JAX)

? Veerasamy “Ravi” Ravichandran (NIH / NIGMS)

Karen Ross (Delaware)

Alan Ruttenberg (Buffalo)

Cynthia Smith (JAX)

Barry Smith (Buffalo)

Kimberley VanAuken (CalTech)

Laurens Wilming (JAX)

Cathy Wu (Delaware / PRO)

Please contact Barry Smith for further information.

Sponsors

The Protein Ontology Consortium

National Center for Ontological Research