PRO Consortium Workshop 2019

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Date: October 23-24, 2019

Venue:

Protein Informatics Resource
Georgetown University Medical Center
3300 Whitehaven Street, NW, Suite 1200
Washington, DC 20007, USA


Goals

The goals of this meeting are:

  • 1. To plan the future of the PRO
  • 2. To foster PRO's collaborations with other initiatives

Schedule: Wednesday, October 23, 2019

8:30 Breakfast

PRO as a framework for advancing disease understanding

Chair: Darren Natale

9:00 General introduction to PRO (Darren Natale)
Protein aggregates (Alexander Diehl)
PRO sites (Alan Ruttenberg)
10:30-10:45 Break

Disease mechanisms: connecting clinically-relevant protein sequence variations with their impact on underlying molecular mechanisms. Part 1

Chair: Judith Blake

10:45 Mouse models of human disease (TBD)
11:15 UniProt
UniProt (Alexander Bateman)
UniProtKB's molecular impact information (Harold Drabkin?)
There is a need for standardization of information found on UniProtKB's mutation feature lines. Currently this information is provided as free text. It needs to be connected to various ontologies, including the GO. For example, some mutation might abolish some function that could be described using GO.
12:30-13:30 Lunch

Disease mechanisms: connecting clinically-relevant protein sequence variations with their impact on underlying molecular mechanisms. Part 2

13:30
Disease Ontology (Melody Swan)
Ontology for General Medical Science (Barry Smith)
Discovering molecular mechanisms underlying disease (Karen Ross, Natarajan Kannan)
15:30-16:00 Break
17:30 Close of Day 1
18:00 Working dinner

Schedule: Thursday, October 24, 2019

8:15 Breakfast

Clinical discovery: connecting clinically-relevant information to proteoforms and complexes

Chair: Peter d'Eustachio

8:45 Connecting proteins to disease using disease pathways (Peter d'Eustachio)
Drug targets (Stephan Schürer)
Connecting antibodies to epitopes and proteins (Randi Vita)
10:30-11:00 Break

Cell type discovery: connecting proteoform expression profiles with clinically-relevant cell types

Chair: Alexander Diehl

11:00 Introduction (Alexander Diehl)
scRNA from KPMP (Oliver He)
Proteoform-based cell type dictionary (Alex Diehl)
12:30-1:30 Lunch
13:30 Working Session (on Grant Proposal)
15:00 Close

Participants

Alexander Bateman (EBI)*
Alexander Diehl (Buffalo)
Cecilia Arighi (Delaware / PRO)
Judith Blake (JAX)
Peter d'Eustachio (NYU)
Alexander Diehl (Buffalo)
Harold Drabkin (JAX)
Yongqun (Oliver) He (Michigan)
Natarajan Kannan (Georgia)
Richard LeDuc (Northwestern)
Birgit Meldal (EBI)*
Darren Natale (Georgetown)
? Li Ni (JAX)
Karen Ross (Georgetown)
Alan Ruttenberg (Buffalo)
Stephan Schürer (Miami)
Barry Smith (Buffalo)
Christian Stoeckert (Penn)
Melogy Swan (Baltimore)
Paul Martin Thomas (Northwestern)
Randi Vita (San Diego)
Cathy Wu (Delaware / PRO)
  • =online


Please contact Barry Smith for further information.

Sponsors

The Protein Ontology Consortium
National Center for Ontological Research